In July 2018 researchers from New Zealand published the results of their study to assess the effect of coffee intake on serum urate concentrations and risk of gout. 130,966 European participants aged 40-69 years were included in the study. Results showed that an increased coffee consumption reduced the risk of gout. Analysis revealed that urate-increasing alleles were associated with a reduced daily coffee consumption although certain alleles influenced the risk of gout directly, rather than indirectly through coffee consumption.
Hutton J et al. Mediation analysis to understand genetic relationships between habitual coffee intake and gout. Arthritis Res Ther. 2018 Jul 5;20(1):135