In December 2018 researchers from Saudi Arabia, Malaysia and Pakistan published their review of the medical scientific literature to assess the effect of hyaluronic acid on skin rejuvenation. Results showed that hyaluronic acid–based formulations, eg gels, creams, intra-dermal filler injections, dermal fillers, facial fillers, autologous fat gels, lotion, serum, and implants appeared to show anti-wrinkle, anti-aging, and face rejuvenating properties. This was achieved via improved skin hydration, collagen and elastin stimulation, and face volume restoration. Hyaluronic acid, either alone or in combination with other ingredients, was effective at improving skin tightness and elasticity and reducing wrinkle scars.
Bukhari SNA et al. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol. 2018 Dec;120(Pt B):1682-1695