In June 2019 researchers from Iran published their review of the medical scientific literature to assess the relationship between vitamin D deficiency and rheumatoid arthritis. Most studies reported that a low intake of vitamin D increased the risk of rheumatoid arthritis and that vitamin D deficiency was associated with a high level of rheumatoid arthritis activity. Results of studies assessing the effect of vitamin D supplementation in rheumatoid arthritis have been seen to vary, ranging from no effect to a significant improvement in disease activity, including an improved quality of life. However, this could be attributed to differences in vitamin D dosages, duration of treatment, initial vitamin D levels in individuals with rheumatoid arthritis as well as the characteristics of rheumatoid arthritis. The researchers concluded that there may be a role for vitamin D supplementation in the treatment of individuals with rheumatoid arthritis although further research is required to identify an effective dosage, duration of treatment and patients who will benefit most from the treatment.
Heidari B et al. Vitamin D Deficiency and Rheumatoid Arthritis: Epidemiological, Immunological, Clinical and Therapeutic Aspects. Mediterr J Rheumatol. 2019 Jun 29;30(2):94-102
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